Tirzepatide vs Semaglutide: Unveiling Uses, Benefits, And Side Effects


There has been a debate for a long time about which one is more beneficial in the effective reduction of body weight and HbA1c in people. Taking drugs for weight loss and reducing blood sugar levels has been a trend for some people who want the results more quickly. Not only do these drugs affect your gastrointestinal tracts, but they also reduce life expectancy. Making sure that you are opting for natural and more healthy ways to reduce your weight is the best choice. Let’s take a look at Tirzepatide vs Semaglutide and understand its uses and side effects.

If you are trying to get rid of your diabetes, it is unlikely that it will completely go away. However, controlling the effects and symptoms is in your hands. Make sure you are getting all the nutrition without taking sugar in your diet, stay hydrated, and stay physically active. Anyway, here in this article, you are going to learn about the effects of weight loss drugs like semaglutide and tripeptide on your body.

What Are Tirzepatide And Semaglutides?

Weight loss drugs like tripeptide and semaglutide are often used for weight loss and treating type-2 diabetes. Usually, doctors recommend some people use one of these drugs for weight loss and maintaining blood sugar levels. These drugs are capable of making your brain feel less hungry, which leads to less appetite, and eventually, you lose weight. These drugs are also efficient in regulating glycemic control in adults with type-2 diabetes.

Tirzepatide vs Semaglutide

Maintaining the insulin production in your intestines, terzepatide is also more efficient in reducing your weight than semaglutide. The main concern about terzepatide is that more dosage of this drug is effective, which can increase the risks of gastrointestinal events.

Which One Is More Potent?

A recent network meta-analysis has proved that terzepatide is more efficient in weight reduction and reduction in HbA1c in people with type-2 diabetes. Semaglutide is also effective in the same aspects, but taking terzepatide will prove to give results faster and effectively. According to the results of this analysis, it was found that teriparatide was given more dosage in comparison to semaglutide for it to work effectively. 

As there is only limited research and proof of the drug being more effective, there is no certainty of these drugs being effective on everyone. Everyone has a different metabolism and immune system, and allergic responses are also to be considered. When it comes to the potency of one of these drugs, terzepatide is more effective, according to limited research.

What Are The Differences Between Both Drugs?

Now, a meta-analysis has surfaced stating that terzepatide is more efficient than semaglutide in reducing blood sugar and body weight. The result was concluded after taking the data from 22 people with type-2 diabetes, and it was stated that 5, 10, and 15 mg of tripeptide was more beneficial than 0.1, 0.5, and 1 mg of semaglutide in blood sugar and body weight reduction.

There are not many basic differences between the two drugs, as both are glucose-dependent insulinotropic polypeptide or glucagon-like peptide receptor agonists. Both of the drugs work in the same manner, which is to regulate glycemic control, tricking the brain into feeling less hungry and losing weight. Both of the drugs help a person reduce weight and reduce blood sugar levels.

What Are The Possible Side Effects Of Tirzepatide And Semaglutides?

When it comes to side effects of weight loss drugs like semaglutide and terzepatide, these can commonly have mild side effects. Having simple side effects like diarrhea and headache doesn’t mean that it won’t affect your health in the long term. These drugs are made to mimic the effects of hormones like ghrelin and leptin. These hormones are responsible for your food cravings and hunger. 

When a person takes drugs like semaglutide or terzepatide, polypeptides present in them start to mimic and lower the production of food-craving hormones. This process tricks your brain into feeling less hunger and cravings.

Anyway, here are all the side effects that you can have if you take weight loss drugs like these two:

1. Possible Allergic Reactions

Every person has a different immune system and related responses against outside materials. Suddenly exposing your immune system to these weight-loss drugs can induce some allergic responses like rashes and severe nausea. There have been recent lawsuits and court hearings regarding the excessive usage of these drugs, which led to the deaths of many people. So, taking the drug with precaution and checking will be beneficial for you.

2. Mild Side Effects

Usually, people suffer from mild side effects after taking weight loss drugs. The most common side effects are nausea, constipation, fatigue, headache, and increased heart rate. Usually, these effects are not life-threatening but can have negative effects on heart health and nervous system in the long term. 

Mild side effects are caused by the systematic response of your immune system to polypeptides present in these drugs. These side effects go away when your body gets adapted to the usage and accepts these in your body.

3. Serious Side Effects

Normally, people don’t have any serious side effects related to the usage of semaglutide and terzepatide. However, there have been some cases in which people have suffered more serious issues like vulvar diseases. As weight loss drugs like these two can increase your heart rate, people with cardiovascular conditions should strictly stay away from them. There have been cases in which people have increased risks of CVDs in the future.

Summing Up

Taking weight loss drugs for your weight loss might sound like an easy and effective way to lose that excess fat from your body. However, contracting future risks of CVDs and risk of allergies makes them unworthy of trying. These drugs mimic the natural production of your food-craving hormones and can lead to a lack of nutrition whatsoever. 

It has been shown in an analysis that Terzepatide is more effective in weight loss and helping with type-2 diabetes. However, there isn’t much research and studies on these drugs, which makes it experimental and can lead to adverse effects you wouldn’t want. It was also found in the analysis that terzepatide was given in more dosages to people for positive effects in comparison to semaglutide, so stay aware.


  • Garvey WT, Mechanick JI, Brett EM, et al. American Association of Clinical Endocrinologists and American College of endocrinology comprehensive clinical practice guidelines for medical care of patients with obesity. Endocr Pract. 2016; 22: 1-203. PUBMED
  • Di Angelantonio E, Bhupathiraju ShN, Wormser D, et al. Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents. Lancet 2016;388:776-786. Crossref

Our recommendations are rooted in genuine belief in the benefits of the products bring to users. When you purchase through our links, we may earn a commission, supporting our testing and development without adding any cost for you. Learn more.

Dr. David G Kiely is a distinguished Medical Reviewer and former General Medicine Consultant with a wealth of experience in the field. Dr. Kiely's notable career as a General Medicine Consultant highlights his significant contributions to the medical field.

Learn More

Leave a Comment